Penicillin: The First Miracle Antibiotic
About Penicillin: Alexander Fleming, a Scottish bacteriologist, accidentally discovered Penicillin in 1928, while working on a plate of Staphylococcus which was contaminated by a fungal growth. Fleming noticed that the bacterial colonies around the fungal growth had been dissolved. After growing the mold in a culture, he found that it produced a substance which inhibited the growth of many organisms. He named the substance Penicillin, after the fungus producing it, Penicillium notatum. Penicillin is a narrow spectrum antibiotic which is the first of the class of beta - lactam group of antibiotics. Over the years, unrestricted and overzealous usage of Penicillin has lead to emergence of multiple organisms with complete resistance to the drug. Penicillin includes Penicillin G, Penicillin V, Benzathine and Procaine Penicillin.
How Penicillin Works: Penicillin falls under the class of beta - lactam group of antibiotics. It attaches to the enzyme DD - transcriptase and does not allow the action of the enzyme to take place, which is the formation of cross - linked peptidoglycan bonds in the cell wall of the bacteria. The bacterial cell wall is degraded at a normal pace and the cell wall creation is unable to keep up, due to the defective enzyme action. Thus Penicillin causes defects to form in the cell membrane, allowing the contents of the cell to leak out, eventually causing death of the bacteria.
How To Take Penicillin: Today, Penicillin usage is restricted to treatment of a few infections where the bacteria are still susceptible. These are streptococcal infections like pharyngitis, otitis media and rheumatic fever, meningococcal meningitis, gonorrhoea, syphilis, diphtheria, tetanus, gas gangrene and rarer infections like anthrax, leptospirosis, rat bite fever and trench mouth. Buy Penicillin is used in the prophylaxis of rheumatic fever, bacterial endocarditis and in patients with agranulocytosis. Crystalline Penicillin Without Prescription (Penicillin G) is used in the dose of 0.5 - 5 million units intravenous or intramuscular, at an interval of 6 - 12 hourly doses. The duration of treatment varies according to the infection. Procaine Penicillin is longer acting and can be used at intervals of 12 - 24 hrs. Benzathine Penicillin is very long acting and is used in a dose of 0.6 - 2.4 million units intramuscular every 2 - 4 weeks. This is the preparation used commonly for rheumatic fever prophylaxis. Penicillin No Prescription injectable preparations are available as a powder to be reconstituted in sterile water, or as an aqueous suspension. The oral tablet form of Penicillin is Penicillin V potassium. It is available in strengths of 250 mg (400,000 units) and 500 mg (800,000 units). Treatment with Penicillin VK is indicated only in mild to moderately severe infections by bacteria susceptible to Penicillin G, in a dosage of 250 mg - 500 mg every 6 - 8 hours for a period of 7 - 10 days.
Precautions And Interactions: Buy Penicillin No Prescription has the propensity to cause serious and life threatening allergic reactions. Fatal hypersensitivity reactions in the form of anaphylaxis have been reported. A proper allergy history of the patient and a sensitivity testing in a proper facility is mandatory prior to starting any patient on Penicillin therapy. Patients with renal failure or decreased kidney function should be prescribed Penicillin No Prescription with caution.
Side Effects Of Penicillin: Hypersensitivity reactions of varying intensity are common with the use of Buy Penicillin Without Prescription, and appropriate precautions must be taken. Local irritation, thrombophlebitis and pain at injection site are also frequently seen. Occasionally systemic toxicity can be seen in patients given large doses of Buy Penicillin, especially in those with renal insufficiency. Super - infections, especially with Clostridium difficile are possible when on Penicillin Without Prescription therapy, especially when using the oral form.